2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-D1528
    MTSEA-Fluorescein 1356019-48-1 98%
    MTSEA-Fluorescein is a fluorescent probe that can be used for ion channel research.
    MTSEA-Fluorescein
  • HY-D1536
    Glycine cresol red 77031-64-2 98%
    Glycine cresol red is a complexometric indicator. Glycine cresol red forms coloured complexes with Al3+, Ga3+ and In3+ ions in aqueous solutions. Glycine cresol red can been used for the spectrophotometric determination of inorganic ions. Glycine cresol red can be used as a stain in neurohistology.
    Glycine cresol red
  • HY-D1672
    TMR Biocytin 749247-49-2 98%
    TMR Biocytin is a polar tracer used in the research of cell-cell and cell-liposome fusions, as well as membrane permeability and cellular uptake during pinocytosis. TMR Biocytin can be detected using streptavidin, and is an effective neuronal tracer in live tissue (Ex=544 nm, Em=571 nm).
    TMR Biocytin
  • HY-D1684
    DCDAPH 125113-96-4 98%
    DCDAPH (Compound 2c) is a novel smart NIRF probe for detection of β-amyloid (Aβ) plaques (λex/λem=597/665 nm in PBS). DCDAPH shows high affinity for Aβ aggregates (Ki=37 nM, Kd=27 nM). DCDAPH shows good blood brain barrier permeation and can meet most of the requirements for the detection of Aβ plaques both in vitro and in vivo.
    DCDAPH
  • HY-D1704
    Bodipy TMR-X muscimol 849464-08-0 98%
    Bodipy TMR-X muscimol is a Bodipy labeled Muscimol (HY-N2313) (Ex=543 nm, Em=572 nm). Muscimol is a GABAA agonist. Bodipy TMR-X muscimol can be used for imaging the spread of reversible brain inactivations.
    Bodipy TMR-X muscimol
  • HY-D2260
    hMSCs-Neu perchlorate 2320522-38-9 98%
    hMSCs-Neu perchlorate (Compound 4) is a fluorescent probe that converts hMSCs into neurons in the presence of fibroblast growth factor (FGF). hMSCs-Neu perchlorate may have important applications in neuropathology and neurodegeneration research.
    hMSCs-Neu perchlorate
  • HY-D2266
    FluoBar1 98%
    FluoBar1 is an imaging fluorescence probe modified by a barbiturate ligand with fluorescent coumarin. FluoBar1 can monitor L-type voltage-gated calcium channels (LTCC) in living cells in real time for the study of neurological diseases .
    FluoBar1
  • HY-D2335
    SERTlight 98%
    SERTlight is a fluorescent agent that can specifically label serotonergic neuronal cell bodies, dendrites, and axonal projections as fluorescent substrates of the serotonin transporter (SERT). SERTlight is orthogonal to various genetically encoded sensors in terms of optics, pharmacology, and operation, enabling multiple imaging. SERTlight allows the use of GRAB5HT sensors to label distal 5HT axonal projections and simultaneously image the release of endogenous 5HT, providing a new multifunctional molecular tool for studying serotonergic systems.
    SERTlight
  • HY-D2343
    PB0822 98%
    PB0822 can be used for in vivo PET imaging when labeled with [18F]fluoride. [18F]PB0822 is a PET radioligand. [18F]PB0822 has a cLogP value of 1.54, which is a good predictive index for BBB penetration. [18F]PB0822 can be used for Alzheimer’s Disease research.
    PB0822
  • HY-D2844
    FITC-PEG-FA (MW 400) 98%
    FITC-PEG-FA (MW 400) is a fluorescent dye composed of Folic acid (HY-16637) (FA), polyethylene glycol (PEG) and FITC (HY-66019). Fluorescent dye is linked to PEG and Folic acid through a specific chemical reaction to form a molecule with special properties. FITC-PEG-FA (MW 400) can be used for fluorescent labeling and imaging.
    FITC-PEG-FA (MW 400)
  • HY-G0025
    Tetrabenazine Metabolite 924854-60-4 98%
    Tetrabenazine Metabolite is an active metabolite of Tetrabenazine. Tetrabenazine Metabolite is a vesicular monoamine transporter 2 (VMAT2) inhibitor with a high affinity (Ki=13.4 nM). Tetrabenazine Metabolite is be developed for the treatment of chorea associated with Huntington’s disease and other hyperkinetic disorders.
    Tetrabenazine Metabolite
  • HY-N0065
    Eudesmol 51317-08-9 98%
    Eudesmol is a sesquiterpenoid compound produced by Streptomyces tendae.
    Eudesmol
  • HY-N0491
    (-)-Sparteine sulfate 299-39-8 98%
    (-)-Sparteine (sulfate) is a quinolizidine alkaloid that can be extracted from Lupinus. (-)-Sparteine (sulfate) inhibits the release of acetylcholine and has anticonvulsant effects.
    (-)-Sparteine sulfate
  • HY-N0581
    Qingyangshengenin A 106644-33-1 99.25%
    Qingyangshengenin A, a C-21 steroidal glycoside isolated from the roots of Cynanchum otophyllum Schneid, has antiepileptic activity.
    Qingyangshengenin A
  • HY-N0949
    (-)-Variabilin 370102-93-5 98%
    (-)-Variabilin (compound 13) is an Neurogenin2 (Ngn2) promoter activator isolated from Butea superba. (-)-Variabilin promotes differentiation of neural stem cells into neurons.
    (-)-Variabilin
  • HY-N1064
    Xanthoplanine 6872-88-4 98%
    Xanthoplanine, isolated from theroot of Xylopia parviflora, fully inhibits the EC50 ACh responses of both alpha7 and alpha4beta2 nACh receptors with estimated IC50 values of 9 μM (alpha7) and 5 μM (alpha4beta2).
    Xanthoplanine
  • HY-N1151
    Thunberginol C 147517-06-4 98%
    Thunberginol C is a natural product that can be isolated from Hydrangea macrophyll. Thunberginol C attenuates stress-induced anxiety. Thunberginol C also has antimicrobial and antiallergic activity.
    Thunberginol C
  • HY-N1317
    Salirepin 26652-12-0 98%
    Salirepin is a phenolic glycoside from fruits of Idesia polycarpa, inhibits LPS-induced nitric oxide production.
    Salirepin
  • HY-N1523
    Rengyol 93675-85-5 98%
    Rengyol (Cleroindicin A), a natural alcohol compound, is an inhibitor of emesis induced by copper sulfate pentahydrate.
    Rengyol
  • HY-N1636
    1-Methyl-2-nonyl-4(1H)-quinolone 68353-24-2 98%
    1-Methyl-2-nonyl-4(1H)-quinolone, a quinolone alkaloid, is a potent and selective MAO-B (monoamine oxidase) inhibitor. 1-Methyl-2-nonyl-4(1H)-quinolone exhibites inhibitory activity on leukotriene biosynthesis, with an IC50 of 12.1 μM.
    1-Methyl-2-nonyl-4(1H)-quinolone
Cat. No. Product Name / Synonyms Application Reactivity